It is currently Fri Oct 20, 2017 12:40 am

All times are UTC [ DST ]




Post new topic Reply to topic  [ 43 posts ]  Go to page 1, 2, 3  Next
Author Message
PostPosted: Fri Mar 25, 2011 12:53 pm 
Offline
Bengal Kitten

Joined: Thu Jan 15, 2009 12:40 pm
Posts: 23
Please be aware that it has come to my attention that PKDef has been spread among the bengal genes. PKDef has nothing to do with PKD, Polycystic Kidney Disease.

Pyruvate kinase (PK) deficiency is an inherited disease occasionally encountered in Abyssinian and Somali cats, and also reported in the domestic shorthair cat. Pyruvate kinase is an enzyme found within red blood cells which enables them to produce energy to survive. If this enzyme is lacking, the lifespan of the red blood cells is significantly reduced, resulting in a reduction in the number of red blood cells in the circulation (anaemia).

http://www.fabcats.org/owners/pk_deficiency/info.html

The symptoms in affected kittens can be very easily mistaken for FIP. If you had FIP kittens and it was not confirmed by autopsy, it can be useful to get your cats tested for PKDef. There is a new simple one-time swap test available at UC Davis. https://www.vgl.ucdavis.edu/

Mind you, I know what I am talking about. One of my queens turned out to be a carrier (one ill gene).
Edit April 30th: and our stud turned out to be an affected cat (two ill genes) which means the poor guy will certainly die of this horrible disease. Nobody can predict when, but it is inevitable

Here in the Netherlands and in Germany, more and more bengals turn out to be carriers. We only found out because we started testing them. We got the heads up from a German breeder we thank her for that! If it is spread in our bengals, chances are it is spread in your bengals as well.

There is no reason to panic not to breed a carrier (one ill gene) just as long as the partner is not a carrier as well. Kittens from those matings should be tested if they will be used for breeding again.
Affected cats, with 2 ill genes, officially should be neutered for their own health sakes but I recently learned most PKDef affected cats die on the operation table or shortly after. We are still uncertain if we might try chemical castration for our stud. One thing will be sure: we'll get him a pampered rest of his life.

Get your bengals tested. It can save you and your kitten buyers a lot of grieve.

_________________
Ilona
Cattery Ifness, The Netherlands
Image
http://www.ifness.com/bengaal/


Last edited by Ifness on Sat Apr 30, 2011 1:10 pm, edited 6 times in total.

Top
 Profile  
 
 Post subject:
PostPosted: Fri Mar 25, 2011 1:28 pm 
Offline
Asian Leopard Cat

Joined: Mon Aug 20, 2007 2:54 pm
Posts: 10875
Location: Cumbria, UK
That's really interesting, thanks for posting. It's especially interesting how it can be mistaken for FIP. I don't know if it's just because I come into contact with more Bengal owners over time, but it does seem to me that FIP-like symptoms are being reported more regularly and I have been wondering if they are all FIP or not. Tragically it probably doesn't change the outcome for the poor owner but knowledge is vital for future generations.

_________________
Image
Image


Top
 Profile  
 
 Post subject:
PostPosted: Fri Mar 25, 2011 7:14 pm 
Offline
Asian Leopard Cat

Joined: Sun Feb 15, 2009 6:28 am
Posts: 6038
Location: UK
very interesting, is it ok to cross post this? xx

_________________
Image
Image

Miki & My Beloved Bengals http://mybelovedbengals.blogspot.com/

Shiloh, Darcy, Rudy The Roodster & Ozzy...


Top
 Profile  
 
 Post subject:
PostPosted: Fri Mar 25, 2011 7:54 pm 
Offline
Bengal Kitten

Joined: Thu Jan 15, 2009 12:40 pm
Posts: 23
miki129 wrote:
very interesting, is it ok to cross post this? xx


Please do! The more breeders are informed, the better the outcome for all those cats.

Thanks a lot!

_________________
Ilona
Cattery Ifness, The Netherlands
Image
http://www.ifness.com/bengaal/


Top
 Profile  
 
 Post subject:
PostPosted: Sat Apr 30, 2011 12:14 pm 
Offline
Bengal Cat

Joined: Thu Jan 15, 2009 1:16 pm
Posts: 26
Location: Amsterdam, the Netherlands
http://www.bengalcatforums.com/forums/v ... 551#154551

_________________
Image


Top
 Profile  
 
 Post subject:
PostPosted: Sat Apr 30, 2011 1:09 pm 
Offline
Asian Leopard Cat

Joined: Tue Jan 12, 2010 8:08 pm
Posts: 2927
Location: West Midlands, UK
Thank you for the information - how do we test in the UK for this?

Do we apply for a swab kit from the Lab in the us - swab and then send back?

Does anyone know if this test is something Idexx lab in this country can do?

ETA sorry I should learn to read properly I see now Bristol University are able to do the swab test

_________________
Image
Image
BBUKU Website


Top
 Profile  
 
 Post subject:
PostPosted: Sat Apr 30, 2011 1:14 pm 
Offline
Bengal Kitten

Joined: Thu Jan 15, 2009 12:40 pm
Posts: 23
UC Davis testing is very simple. You make a login, choose your tests. Pay with credit card or ask for a banknumber for a transfer. You'll get the right documents and instructions in your mail. You print out the documents, do a swap on each cat with a Q tip and send it in. They will confirm by mail when your tests have arrived and about 5-7 workdays later, you'll get the results also in mail.

_________________
Ilona
Cattery Ifness, The Netherlands
Image
http://www.ifness.com/bengaal/


Top
 Profile  
 
 Post subject: PK Def
PostPosted: Fri Jun 10, 2011 12:40 pm 
Offline
Asian Leopard Cat

Joined: Mon Dec 10, 2007 2:23 pm
Posts: 130
Location: Lancashire/n yorks
Langford at Bristol test for this. Cost is £30 though some clubs have a code for a 20% discount.
PLEASE do test for this, so far 2 breeders have tested with carriers found from 2 totally unrelated uk lines...
You just need a cotton wool bud for a mouth swab...
wendy

_________________
Proud servant of Amber the snow spot and her brown spot daughter Tilly.


Top
 Profile  
 
 Post subject:
PostPosted: Sat Jun 11, 2011 8:38 pm 
Offline
Asian Leopard Cat

Joined: Mon Dec 10, 2007 2:23 pm
Posts: 130
Location: Lancashire/n yorks
Forwarded by request from from Steven Robertson...

Good moves being made regarding PK Def. The FAB and GCCF are both looking into this. The GCCF are in contact with Urs Giger who found this and was one who developed the test. As this is currently the only concerted effort they really need more results.

If you are or have tested and found any carriers or positives would you send your results and pedigree(s) to Jen Lacey; the contact for the GCCF genetics committee. This is what she asked to tell people :
"The results and the pedigrees are what's needed, and they must understand they'll be sharing them with GCCF Genetics Committee, Veterinary Committee and probably the senior vets in this field at Langford."

From their initial enquiries the water is VERY murky on this subject so hopefully the more pedigrees and results they get will give us a better indication. Please pass this on to anyone you know who will be testing.

Jen's e-mail is : jen.lacey@btinternet.com

_________________
Proud servant of Amber the snow spot and her brown spot daughter Tilly.


Top
 Profile  
 
 Post subject:
PostPosted: Fri Jun 17, 2011 2:24 pm 
Offline
Bengal Kitten

Joined: Thu Jun 16, 2011 5:46 pm
Posts: 21
Thank you for this info! I was not aware of this in bengals. I will get my cats tested as soon as possible, although so far no signs of it in my lines, but who knows?

I already used UC Davies for cat colors, they are easy to use, and understand what to do.


Top
 Profile  
 
 Post subject:
PostPosted: Fri Jun 17, 2011 5:04 pm 
Offline
Asian Leopard Cat

Joined: Mon Dec 10, 2007 2:23 pm
Posts: 130
Location: Lancashire/n yorks
There was no sign of it in the lines its been found..
We need people to test and forward results so we can try and find out just how bad the situation is..
wendy

_________________
Proud servant of Amber the snow spot and her brown spot daughter Tilly.


Top
 Profile  
 
 Post subject:
PostPosted: Sun Jun 26, 2011 7:37 pm 
Offline
Asian Leopard Cat

Joined: Mon Dec 10, 2007 2:23 pm
Posts: 130
Location: Lancashire/n yorks
More people have tested their cats and so far its 24% of cats tested are carriers...
Please test, langford do not post any indentifying details, just no of cats testes and results. Its looking scarey at the moment as most of the carriers are not related...

wendy

_________________
Proud servant of Amber the snow spot and her brown spot daughter Tilly.


Top
 Profile  
 
 Post subject:
PostPosted: Sun Jun 26, 2011 8:01 pm 
Offline
Bengal Kitten

Joined: Thu Jan 15, 2009 12:40 pm
Posts: 23
24%? That even worse than our suspection based on what we see in the Netherlands. :-(

_________________
Ilona
Cattery Ifness, The Netherlands
Image
http://www.ifness.com/bengaal/


Top
 Profile  
 
 Post subject:
PostPosted: Sun Jun 26, 2011 8:05 pm 
Offline
Asian Leopard Cat

Joined: Tue Jan 16, 2007 2:47 pm
Posts: 3809
Location: UK
Quote:
More people have tested their cats and so far its 24% of cats tested are carriers...


That is very sad to hear.

_________________
Elaine


Top
 Profile  
 
 Post subject:
PostPosted: Sun Jun 26, 2011 8:16 pm 
Offline
Asian Leopard Cat

Joined: Tue Apr 01, 2008 11:31 am
Posts: 2227
Location: UK
I would also like to point out that for members of the Bengal Cat Club there is a code/link for testing at Langford that includes a discount that results in the bargain testing price of £24 per cat/test!!!!

If you are thinking of testing your cats, now is a good time to join the BCC and get the discount code I think? :wink:

_________________
Best Wishes,
Karen <UK>
http://www.suntouchedbengals.com
http://www.bengalbreedersunited.co.uk
Image
Image


Top
 Profile  
 
Display posts from previous:  Sort by  
Post new topic Reply to topic  [ 43 posts ]  Go to page 1, 2, 3  Next

All times are UTC [ DST ]


Who is online

Users browsing this forum: No registered users and 3 guests


You cannot post new topics in this forum
You cannot reply to topics in this forum
You cannot edit your posts in this forum
You cannot delete your posts in this forum
You cannot post attachments in this forum

Jump to:  
Powered by meemonkey