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 Post subject: PK-Deficiency nightmare
PostPosted: Sat Apr 30, 2011 12:13 pm 
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Bengal Cat

Joined: Thu Jan 15, 2009 1:16 pm
Posts: 26
Location: Amsterdam, the Netherlands
Devastating news. Yesterday we have learned that our beloved Tino has two genes for PK-Deficiency (this is NOT PKD, the kidney-disease!) which makes him PK-deficiency positive.

We are heartbroken. Even though he is perfectly fit now, it is certain that he will die of this horrible disease. Nobody can predict when, but it is inevitable. Even the mental and physical strains of neutering him could cause it to flare up and that could be lethal.
We will make sure he lives the rest of his life as a very much loved and pampered boy with his cat- and dog-friend in my home.

Please, everyone, test your cats!!
http://www.fabcats.org/owners/pk_deficiency/info.html
http://www.vgl.ucdavis.edu/services/pkdeficiency.php

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PostPosted: Sat Apr 30, 2011 12:43 pm 
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Asian Leopard Cat

Joined: Mon Aug 20, 2007 2:54 pm
Posts: 10875
Location: Cumbria, UK
I'm so sorry to hear this. I don't know much about PK deficiency other than what I've read on here. Is Tino just a carrier or does him having 2 genes mean he will definitely develop the symptoms?

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PostPosted: Sat Apr 30, 2011 2:11 pm 
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Asian Leopard Cat

Joined: Tue Jan 16, 2007 2:47 pm
Posts: 3809
Location: UK
It is tragic, such a beautiful cat. :(

From the FAB site:-
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As Naomi has said 2 genes means he has the disease.
He is the "+ + PK def" offspring in the diagram. He got the genes from both sides, so his parents are either carriers or are affected.
All Tino's offspring will be carriers, some may be affected too if their mother is a carrier or is also affected.

It is a simple straightforward test and a horrible disease.
Valentino's pedigree contains cats common to many, many Bengal lines including those in the UK and in the US, so is not a disease to be overlooked.

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PostPosted: Sat Apr 30, 2011 2:52 pm 
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Bengal Cat

Joined: Thu Jan 15, 2009 1:16 pm
Posts: 26
Location: Amsterdam, the Netherlands
Elaine is correct, sadly. Tino is affected and will, at one time or another, show symptoms. Luckily the three females that have litters fathered by Tino are all PK-Def negative. The kittens will be carriers, but won't get sick.

UCDavis has asked us to submit DNA samples of Tino's parents to hopefully validate the DNA-test for Bengals. His breeders will submit those samples and test their other cats to avoid this happening again in the future.

Tino's pedigree: http://www.bengalpedigrees.com/showone. ... icanum=(ES)ASFEL046138&jid=13781
But there are many more lines that are affected. PK-Deficiency originated in Abyssinians and they were used in the Bengal breed. There have been quite a few Dutch breeders who have tested their cats for PK Deficiency. No other PK-Def positive cats so far apart from Tino, but more carriers (cats with one PK-Def gene) than I had expected.

I can't thank Renate Mock enough for informing us breeders of this disease and the posibility of DNA-testing our cats for it.

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PostPosted: Sat Apr 30, 2011 4:14 pm 
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Asian Leopard Cat

Joined: Tue Jan 16, 2007 2:47 pm
Posts: 3809
Location: UK
Yes the Abyssinian is a common ancestor in very many lines. A list of Abyssinian ancestors is available here, though there could be more.
http://bengalpedigrees.com/breedsearch. ... abyssinian

Of course the Abysssinian is also behind the Ocicat breed (the Ocicat primarily being an Abyssinian/Siamese cross), of which there are also a lot in Bengal lines.
See - http://bengalpedigrees.com/breedsearch. ... eed=Ocicat

It is thus not a surprise to find PK deficiency in Bengals especially as it has not been previously tested for nor selected against.

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PostPosted: Sat Apr 30, 2011 6:05 pm 
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Bengal Cat

Joined: Thu Jan 15, 2009 1:16 pm
Posts: 26
Location: Amsterdam, the Netherlands
Exactly Elaine.
It is really VERY easy and not expensive ($40 with UCDavis) to take the test. I just made a video to show how easy. The cat is Valentino.
http://www.youtube.com/watch?v=WgyxCafautg

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PostPosted: Sat Apr 30, 2011 6:47 pm 
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Asian Leopard Cat

Joined: Tue Jan 16, 2007 2:47 pm
Posts: 3809
Location: UK
He is a lovely boy, so patient.
Good video.

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 Post subject:
PostPosted: Sun May 01, 2011 11:17 am 
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Asian Leopard Cat

Joined: Tue Jan 16, 2007 2:47 pm
Posts: 3809
Location: UK
This test for PK deficiency can be carried out on young kittens, ie before they leave for their new homes, it is a test that is a one off, it does not need repeated, as the cat's status will not change as it ages, it either is Affected or it isn't and that can be determined at a very young age.

It is thus simple for breeders to choose only Normal or Carrier kittens to breed from.

It is a disease where it is possible to breed a Carrier to a Normal cat and have no Affected kittens at all, only Carriers.
So breeders only need to test their cats once and manage their matings ie Normal to Normal or Normal to Carrier so that no Affected kittens are ever born.

Normal - no PK deficiency genes
If bred to a another Normal cat the offspring will not get PK deficiency nor pass the disease on to their offspring.

Carrier - one PK defic gene, will not be affected by the disease but can pass the PK defic gene on to half of its offspring.
If bred to a Normal - 50% will be Carriers and 50% Normal
If bred to a Carrier - 25% will be Normal, 50% will be Carriers and 25% will be Affected with the disease.

Affected - 2 PK defic. genes - will be affected by the disease.
If bred to a Normal - all offspring will be Carriers
If bred to a Carrier - 50% will be Affected and 50% will be Carriers
If bred to an Affected cat -100% of offspring will be Affected.

The Percentages quoted are statistical and are the probability that an individual kitten will be Affected or Carrier or Normal.
So for instance in an Carrier/Carrier mating each individual kitten runs a risk of 25% that it will be Normal, 50% risk that it will be a Carrier and a 25% risk that it will be Affected.

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 Post subject:
PostPosted: Mon Sep 05, 2011 11:27 pm 
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Bengal Kitten

Joined: Wed Aug 31, 2011 6:53 am
Posts: 5
Didong,

I just wanted to give you a heads up that I found this thread and forum through a Google search because we recently had a cat diagnosed as well. At first it was quite devastating, but threads and communities like these sure seem to help with information and consultation. That and the fact that we were able to find so many deals on pet medical supplies that we at least felt like we weren't the only ones trying.


Last edited by listenmeow on Thu Sep 22, 2011 5:24 pm, edited 1 time in total.

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PostPosted: Thu Sep 15, 2011 8:22 am 
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Asian Leopard Cat

Joined: Tue Jul 20, 2010 9:09 pm
Posts: 977
Location: Surrey, UK
Having been reading these posts, I am now gwtting worried, as if Alfie does test positive, I thought that it meant that it was not likely to be fatal?

Initially we thought it was FIP which I know IS fatal, so now I'm really scared again.

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PostPosted: Thu Sep 15, 2011 10:45 am 
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Asian Leopard Cat

Joined: Tue Jan 12, 2010 8:08 pm
Posts: 2927
Location: West Midlands, UK
I am so so so to hear this - the worst news someone can expect when Pk-def testing...my heart goes out to you and Tino.

It yet again proves how important testing is and imo EVERY breeder should be doing it, its a very affordable and accessible test.

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 Post subject:
PostPosted: Thu Sep 15, 2011 11:55 am 
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Asian Leopard Cat

Joined: Thu Jun 30, 2011 8:12 pm
Posts: 544
Location: South Yorkshire UK
shebajet sadly a PK-Def positive cat can die from the disease in some cases as it can cause severe anaemia although most affected cats only have mild symptoms

http://www.langfordvets.co.uk/lab_pcr_b ... _pkdef.htm

link to the langford information page on PK-Def which explains the symptoms.
I hope that Alfie gets better soon and that he doesn't have FIP!

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 Post subject:
PostPosted: Tue Sep 20, 2011 5:57 pm 
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Asian Leopard Cat

Joined: Tue Aug 15, 2006 2:44 pm
Posts: 360
Location: Devon countryside
It is NOT expensive to have your cat tested at Langford Vets. It is £31.50 and all you need to do is send swabs in the post, so there is no need to transport your cat there. All the information you need is on the Langford website as in previous post.
I'm sure that for every Bengal owner, the small cost of the test will be well worth it for the sake of the breed. If everyone tests, both breeders and pet owners, and acts on the results, then there is less likelihood of many more Bengals being infected in the future.

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 Post subject:
PostPosted: Tue Sep 20, 2011 6:36 pm 
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Asian Leopard Cat

Joined: Mon Aug 20, 2007 2:54 pm
Posts: 10875
Location: Cumbria, UK
My Alfie's father is a carrier for PKDef but I don't think his mum was tested, so I've got a testing kit from Langford Vets to see what his status is. I'm not sure I'll manage to get a sample properly (it needs to be cells from the cheek rather than just saliva) so I plan to ask the vet to do it when he goes for his boosters. I'll do the others when their boosters are due as well.

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