If it's important to you to have this routine, I would make sure there are some incentives for him in it, so that you change his perception of it being a bad thing to it being a good thing. It sounds like he already likes being there, so it shouldn't be a hard sell at all.
Make special treats part of the routine. He gets them when you put him down in his bed or at least arrives in his room. Perhaps you let him smell the treats when you go to pick him up so that he's in anticipation mode. You may even be able to train him, fairly easily, to run into the room on his own accord "when it's time" if the incentives are good enough. You could also make it a quickie play time in there if he is motivated by that.
I don't know why specifically he would hiss and bite. That could mean that there is some pain in the action you are performing (the way you are holding him, or picking him up, or something about his body is tender). I would look real closely for that. If touching him in any specific part of his body causes him to wince or pull back, or lash out. Or just moving your hand towards a specific part of his body causes that reaction (it could be something completely benign too like some cats hate being touched on the stomach or on the bottoms of their feet).
There is an outdoor kitty that I've befriended who comes around my porch pretty frequently. I learned that touching her near her hind quarters is a "no no", and I get smacked if it I do it. She instantly forgives, and loves being touched everywhere else, and adores and is always purry with me, but if you touch her there... WHACK!
_________________ The little monsters 3
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